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Receiver operating characteristic curves for two polygenic risk scores (PRS) containing 180 and 71 single nucleotide polymorphisms (SNPs), respectively. The 180-SNP PRS (A) had an area under the receiver operating characteristic curve (AUROC) of 0.63 (95% CI = 0.62 to 0.64) in seven datasets, excluding City of Hope/ Clinical Cancer Genetics Community Research Network, n = 12 280. The 71-SNP PRS (B) had an AUROC of 0.61 (95% CI = 0.61 to 0.62) in all datasets, n = 13 624.
