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. 2019 Sep 25;112(6):590–598. doi: 10.1093/jnci/djz174

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© The Author(s) 2019. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com.

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Figure 2. — Calibration of two polygenic risk scores (PRS) containing 180 and 71 single nucleotide polymorphisms (SNPs), respectively. Calibration plots for (A) the 180-SNP PRS in seven datasets, excluding City of Hope/ Clinical Cancer Genetics Community Research Network, n = 12 280, and (B) the 71-SNP PRS (B) in all datasets n = 13 624. The graph depicts the predicted vs observed proportions of cases within each decile of the log-normalized PRS. Each circle corresponds to a decile of the PRS, with the middle (largest) circle representing the 40–60th percentile. Two-sided Hosmer-Lemeshow P value = .32 for 180-SNP PRS and .68 for 71-SNP PRS.