Table 2.
Association between 180-SNP and 71-SNP PRS and breast cancer risk
| PRS category | 180-SNP PRS* |
71-SNP PRS† |
||||||
|---|---|---|---|---|---|---|---|---|
| Controls | Cases | odds ratio (95% CI)‡ | P § | Controls | Cases | odds ratio (95% CI)‡ | P § | |
| Continuous PRS (per SD) | 7622 | 4658 | 1.58 (1.52 to 1.64) | 7927 | 5697 | 1.51 (1.46 to 1.56) | ||
| Percentiles of PRS | <.001 | <.001 | ||||||
| <10 | 762 | 196 | 0.46 (0.39 to 0.55) | 793 | 278 | 0.54 (0.47 to 0.64) | ||
| 10–20 | 763 | 223 | 0.52 (0.44 to 0.62) | 792 | 345 | 0.68 (0.58 to 0.79) | ||
| 20–30 | 762 | 340 | 0.80 (0.69 to 0.93) | 793 | 379 | 0.74 (0.64 to 0.86) | ||
| 30–40 | 761 | 335 | 0.79 (0.68 to 0.92) | 792 | 430 | 0.84 (0.73 to 0.97) | ||
| 40–60 | 1525 | 850 | 1 (Referent) | 1587 | 1021 | 1 (Referent) | ||
| 60–70 | 763 | 498 | 1.17 (1.02 to 1.35) | 791 | 656 | 1.29 (1.13 to 1.47) | ||
| 70–80 | 762 | 593 | 1.40 (1.22 to 1.60) | 793 | 694 | 1.36 (1.20 to 1.55) | ||
| 80–90 | 761 | 728 | 1.72 (1.50 to 1.96) | 793 | 832 | 1.63 (1.44 to 1.85) | ||
| >90 | 763 | 895 | 2.10 (1.85 to 2.39) | 793 | 1062 | 2.08 (1.84 to 2.35) | ||
*
Calculated in case-control analysis of seven datasets, excluding City of Hope/Clinical Cancer Genetics Community Research Network (COH/CCGCRN) (n = 12 280). CI = confidence interval; OR = odds ratio; PRS = polygenic risk score; SNP = single nucleotide polymorphism.
†
Calculated in case-control analysis of all datasets (n = 13 624).
‡
odds ratio from multivariable logistic regression of PRS adjusted for study and genetic ancestry.
§
Two-sided P value for the test of the linear trend between per-decile estimates.