Table 3.
AUROCs and ORs per SD of the 71-SNP PRS and 180-SNP PRS in Hispanics, by quartiles of IA ancestry
| IA ancestry category | 180-SNP PRS* |
71-SNP PRS† |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Controls | Cases | AUROC (95% CI)‡ | P § | odds ratio (95% CI)‖ | P ¶ | Controls | Cases | AUROC (95% CI)‡ | P § | odds ratio (95% CI)‖ | P¶ | |
| All | 7622 | 4658 | 0.63 (0.62 to 0.64) | 1.58 (1.52 to 1.64) | 7927 | 5697 | 0.61 (0.61 to 0.62) | 1.51 (1.46 to 1.56) | ||||
| Quartiles of IA ancestry | .56 | .28 | .02 | .01 | ||||||||
| Q1, <0.29 | 2349 | 721 | 0.63 (0.61 to 0.66) | 1.67 (1.52 to 1.83) | 2455 | 951 | 0.64 (0.62 to 0.66) | 1.68 (1.55 to 1.83) | ||||
| Q2, 0.29–0.42 | 2049 | 1021 | 0.61 (0.59 to 0.63) | 1.51 (1.39 to 1.64) | 2117 | 1289 | 0.60 (0.58 to 0.62) | 1.44 (1.34 to 1.55) | ||||
| Q3, 0.42–0.55 | 1820 | 1250 | 0.63 (0.61 to 0.65) | 1.57 (1.45 to 1.69) | 1869 | 1537 | 0.62 (0.60 to 0.63) | 1.52 (1.41 to 1.63) | ||||
| Q4, >0.55 | 1404 | 1666 | 0.63 (0.61 to 0.65) | 1.56 (1.45 to 1.68) | 1486 | 1920 | 0.61 (0.59 to 0.63) | 1.46 (1.36 to 1.56) | ||||
Calculated in case-control analysis of seven datasets, excluding City of Hope/Clinical Cancer Genetics Community Research Network (n = 12 280). AUROC = area under the receiver operating characteristic curve; CI = confidence interval; IA = Indigenous American; OR = odds ratio; PRS = polygenic risk score; SNP single nucleotide polymorphism.
Calculated in case-control analysis of all datasets (n = 13 624).
AUROC from multivariable logistic regression of PRS adjusted for study and genetic ancestry.
Two-sided P value from DeLong’s test of equality of AUROCs between Q1 and Q4 of IA ancestry.
Odds ratio of breast cancer per SD increment of PRS relative to the mean in controls. Calculated from multivariable logistic regression adjusted for study and genetic ancestry.
Two-sided P value for comparison of odds ratio of PRS between Q1 and Q4 of IA ancestry using the Wald test of linear hypothesis.