Table 1.
Components of the computerised decision support tool for comprehensive drug review in people with polypharmacy for chronic diseases
| Components | Data sources |
|---|---|
| Check of indications for current drugs | Evidence-Based Medicine Guidelines and evidence summary collection13 |
| Measurement results (laboratory, anthropometric) with alerts | Evidence-Based Medicine Guidelines13 and consensus of EBMeDS clinical editorial team14 |
| Recommendations about amending current drugs based on best available evidence | EBMeDS evidence based rules and reminders.15 Systematic reviews on drugs commonly prescribed to older people6
16-21
EU(7)-PIM list22 |
| Dosage adjustment in renal malfunction | RENBASE database23 |
| Potentially harmful drug-drug interactions | INXBASE database24 |
| Contraindications | Pharmacological literature and summary of medicinal product characteristics by European Medicines Agency25 |
| Dose warnings | Pharmacological literature and product summaries approved by regulatory authorities |
| Possible adverse drug reactions (risk of bleeding, renal toxicity, risk of seizures, anticholinergic effects, constipation, orthostatism, QT prolongation, sedation, serotonergic effect) | RISKBASE database26 |
EbMeDS=evidence based medicine electronic decision support; EU(7)-PIM=European Union (7)-potentially inappropriate medications.