Table 3.
Primary and secondary outcomes at last follow-up
| Outcomes | Decision support group | Control group | Adjusted comparison estimate (95% CI) | P value (sensitivities) | |||
|---|---|---|---|---|---|---|---|
| No | Estimate* | No | Estimate* | ||||
| Primary outcome | |||||||
| First unplanned hospital admission or death† | 1953 | 997 (51.0%) | 1951 | 1055 (54.1%) | OR: 0.88 (0.73 to 1.07) | 0.19 (MI‡ 0.114) | |
| Sensitivity: time to first unplanned hospital admission or death | 1953 | 0.46 (0.01)§ | 1951 | 0.50 (0.01)§ | HR: 0.93 (0.82 to 1.05) | 0.24 | |
| Key secondary outcome | |||||||
| Last recorded No of drugs | 1953 | 10.12 (3.01) | 1951 | 10.52 (2.94) | Coefficient¶: 0.95 (0.94 to 0.97) | <0.001 (MI<0.001) (BS<0.001) | |
| Sensitivity: change in No of drugs from baseline | 1953 | −0.42 (2.16) | 1951 | 0.06 (2.04) | MD: −0.45 (−0.63 to -0.26) | <0.001 (MI<0.001) (BS<0.001) | |
| Other secondary outcomes | |||||||
| Death† | 1953 | 380 (19.5%) | 1951 | 366 (18.8%) | OR: 1.01 (0.73 to 1.38) | 0.96 | |
| Sensitivity: time to death | 1953 | 0.11 (0.01)§ | 1951 | 0.12 (0.01) § | HR: 0.90 (0.71 to 1.13) | 0.35 | |
| First unplanned hospital admission† | 1953 | 945 (48.4%) | 1951 | 990 (50.7%) | OR: 0.92 (0.76 to 1.10) | 0.36 | |
| Sensitivity: time to hospital admission | 1953 | 0.49 (0.01)§ | 1951 | 0.52 (0.01)§ | HR: 0.95 (0.83 to 1.07) | 0.38 | |
| No of unplanned hospital admission | 1953 | 0.76 (1.24) | 1951 | 0.87 (1.34) | IRR: 0.91(0.69 to 1.20) | 0.51 (BS 0.351) | |
| Duration of unplanned hospital admission (days) | 1949 | 7.89 (17.43) | 1948 | 8.47 (18.18) | IRR: 0.95 (0.67 to 1.35) | 0.79 (BS 0.707) | |
| No of falls over trial period | 1798 | 0.50 (1.26) | 1785 | 0.51 (1.24) | IRR: 1.08 (0.88 to 1.34) | 0.44 (BS 0.287) | |
| ≥1 fractures during trial period | 1953 | 59 (3.0%) | 1951 | 45 (2.3%) | OR: 1.37 (0.87 to 2.16) | 0.17 | |
| SF-12: | |||||||
| Physical component score (0-100) | 1223 | 36.73 (9.44) | 1146 | 36.32 (9.11) | MD: 0.07 (-0.69 to 0.83) | 0.85 | |
| Mental component score (0-100) | 1224 | 46.66 (11.09) | 1145 | 46.27 (11.18) | MD: 0.34 (-0.69 to 1.37) | 0.52 | |
OR=odds ratio; MI=multiple imputation; HR=hazard ratio; BS=bootstrap; MD=mean difference; IRR=incidence rate ratio.
*
Mean (standard deviation) or number (%) unless otherwise indicated.
†
Participants who dropped out were analysed as having reached the endpoint.
‡
Participants who dropped out were analysed using multiple imputation.
§
Estimated proportion (standard error) reaching endpoint by 24 months, from survivor function.
¶
Coefficient represents the adjusted ratio of the number of prescribed drugs in participants assigned to electronic decision support versus those assigned to treatment as usual (control group).