Table 3.

htSNPs with the lowest p-values for the association with risk of rectal cancer, grouped by gene

Rectum
ht SNP ID	OR(95% CI)	p-value for SNP effect	BSGoF-Adjusted p-value
ATM (DSBR)
rs11212592	0.87 (0.80–0.94)	1.67X10−03	2.86X10−03
BLM (DSBR)
rs2518967	1.14 (1.06–1.24)	5.97X10−04	1.35X10−03
rs35787687	1.14 (1.05–1.23)	1.07X10−04	2.32X10−03
DCLRE1C (NHEJ)
rs7920514	1.12 (1.04–1.21)	1.37X10−03	2.50X10−03
PMS1 (MMR)
rs1233258	0.87 (0.80–0.93)	2.37X10−04	7.22X10−04
rs1233262	0.89 (0.83–0.95)	1.21X10−04	2.32X10−03
RAD51B (HR)
rs2189517	1.15 (1.08–1.22)	§5.73X10−06	1.24X10−05
rs12587232	1.13 (1.06–1.20)	4.37X10−05	6.56X10−04
rs187645011	0.71 (0.61–0.84)	7.53X10−05	6.90X10−04
rs7350713	0.74 (0.63–0.87)	2.47X10−04	7.44X10−04
rs6573841	0.86 (0.80–0.93)	3.43X10−04	7.59X10−04
rs111611396	0.74 (0.63–0.87)	3.53X10−04	7.66X10−04
rs1989974	0.76 (0.65–0.88)	4.20X10−04	7.81X10−04
rs117544253	0.72 (0.60–0.86)	4.70X10−04	8.69X10−04
rs77726787	0.74 (0.63–0.87)	4.76X10−04	9.30X10−04
rs8016488	1.15 (1.06–1.25)	5.27X10−04	1.31X10−03
rs11628293	1.12 (1.05–1.20)	6.28X10−04	1.37X10−03
rs113020754	0.75 (0.64–0.88)	6.50X10−04	1.54X10−03
rs80085210	0.74 (0.62–0.88)	9.30X10−04	2.30X10−03
rs113300322	0.77 (0.66–0.90)	9.49X10−04	2.30X10−03
rs74933543	1.11 (1.04–1.19)	1.59X10−03	2.85X10−03

^§statistically significant after Bonferroni’s correction