Table 3. Cardiovascular Death in High Cardiovascular Risk Subgroups After Azithromycin and Amoxicillin Exposure.
| Subgroup | Azithromycin | Amoxicillin | Adjustedb | |||||
|---|---|---|---|---|---|---|---|---|
| No. | Cumulative Incidencea | No. | Cumulative incidencea | Risk difference (95% CI) | Hazard ratio (95% CI) | |||
| Prescriptions | Deaths | Prescriptions | Deaths | |||||
| Prior CV disease | 197 379 | 47 | NA | 571 728 | 81 | NA | NA | NA |
| 0-5 d | NA | 30 | 153.13 | NA | 50 | 88.01 | 51.47 (−8.73 to 157.40) | 1.58 (0.90 to 2.79) |
| 6-10 d | NA | 17 | 89.57 | NA | 31 | 55.82 | 25.69 (−14.10 to 103.43) | 1.46 (0.75 to 2.85) |
| Top decile CVRS | 139 290 | 57 | NA | 574 234 | 120 | NA | NA | NA |
| 0-5 d | NA | 37 | 268.33 | NA | 69 | 120.91 | 85.48 (6.80 to 212.66) | 1.71 (1.06 to 2.76) |
| 6-10 d | NA | 20 | 149.83 | NA | 51 | 91.20 | 24.00 (−25.79 to 111.68) | 1.26 (0.72 to 2.22) |
Abbreviations: CV, cardiovascular; CVRS, cardiovascular risk score; NA, not applicable.
a
Per 1 000 000 prescriptions.
b
Adjusted for propensity score decile, age, and sex.