Table 3.

Effect of B. abyssinica crude extract and solvent fractions on body weight and rectal temperature of P. berghei-infected mice in the 4-day suppressive test.

Group	Body weight (g) ± SEM			Rectal temperature (°c) ± SEM
	D0	D4	% change	D0	D4	% change
DW 10 ml/kg∗	30.26 ± 0.55	28.00 ± 0.58	−7.47	36.70 ± 0.30	34.02 ± 0.22	−7.30
BA 100 mg/kg	27.42 ± 1.11	26.42 ± 0.86	−3.89	36.68 ± 0.19	35.25 ± 0.36	−3.77
BA 200 mg/kg	28.38 ± 0.51	27.51 ± 0.81	−3.14	36.35 ± 0.28	34.97 ± 0.21	−3.79
BA 400 mg/kg	28.76 ± 0.81	27.85 ± 0.95	−3.24	36.35 ± 0.28	35.08 ± 0.18	−3.48
CQ 25 mg/kg∗	27.94 ± 1.49	28.02 ± 1.36	0.29a3	36.13 ± 0.71	36.15 ± 0.15	0.08a3
DW 10 ml/kg	30.04 ± 1.78	25.39 ± 1.24	−15.48	36.18 ± 0.12	34.72 ± 0.32	−4.04
AQ 100 mg/kg	26.99 ± 0.76	24.38 ± 0.53	−8.27	36.48 ± 0.23	35.88 ± 0.22	−1.64
AQ 200 mg/kg	28.48 ± 1.02	26.64 ± 1.06	−6.46	36.52 ± 0.21	35.92 ± 0.18	−1.63
AQ 400 mg/kg	27.52 ± 0.68	26.21 ± 1.65	−5.03	36.34 ± 0.14	35.76 ± 0.81	−1.51
EA 100 mg/kg	31.73 ± 0.90	29.14 ± 1.16	−7.32	36.42 ± 0.26	35.90 ± 0.23	−1.79
EA 200 mg/kg	29.40 ± 0.76	27.32 ± 1.39	−7.07	36.37 ± 0.16	35.72 ± 0.36	−1.79
EA 400 mg/kg	32.57 ± 1.36	29.91 ± 1.41	−8.15	36.20 ± 0.23	35.80 ± 0.20	−1.10
CH 100 mg/kg	31.15 ± 0.45	28.28 ± 0.71	−9.19b1	36.20 ± 0.18	34.92 ± 0.31	−3.54b3
CH 200 mg/kg	29.43 ± 1.13	26.71 ± 0.43	−9.24b1	35.95 ± 0.22	34.85 ± 0.28	−3.06b2
CH 400 mg/kg	30.30 ± 1.34	27.63 ± 1.09	−8.81b1	35.82 ± 0.23	34.87 ± 0.35	−2.65b2
CQ 25 mg/kg	26.19 ± 1.11	26.43 ± 1.03	0.92a3	35.92 ± 0.28	36.57 ± 0.18	1.81a3

Data are expressed as mean ± SEM; n = 6, a = compared to distilled water, b = compared to chloroquine 25 mg/kg, 1 = P < 0.05, 2 = P < 0.01, 3 = P < 0.001, ^∗ = negative and positive controls used for crude extract in the 4 day suppressive test, DW = distilled water, BA = B. abyssinica crude extract, EA = ethyl acetate fraction, CH = chloroform fraction AQ = aqueous fraction, CQ = chloroquine, SEM = standard error of mean, D0 = day 0, and D4 = day 4.