Table 4.
Group | % parasitemia (±SEM) | % suppression | MST (days) | ||||
---|---|---|---|---|---|---|---|
D3 | D4 | D5 | D6 | D7 | |||
DW 10 ml/kg | 21.63 ± 0.33 | 23.72 ± 0.68 | 25.27 ± 1.61 | 27.12 ± 0.78 | 29.68 ± 0.82 | 0.00 | 8.17 ± 0.48 |
BA 100 mg/kg | 24.01 ± 0.48 | 24.30 ± 0.70 | 22.67 ± 0.92b3 | 21.57 ± 1.64b3 | 19.95 ± 1.42a3,b3 | 34.37a3,b3 | 13.29 ± 1.41b3 |
BA 200 mg/kg | 24.92 ± 0.83 | 24.07 ± 1.00 | 23.42 ± 1.36b3 | 22.05 ± 2.91b3 | 16.86 ± 1.08a3,b3 | 43.19a3,b3 | 14.50 ± 1.82a2,b3 |
BA 400 mg/kg | 25.05 ± 0.75 | 24.13 ± 0.76 | 21.87 ± 0.59b3 | 19.75 ± 0.99b3 | 12.48 ± 0.77a3,b3,c3,d1 | 57.94a3,b3,c3,d1 | 16.67 ± 0.49a3,b3 |
AQ 100 mg/kg | 24.88 ± 0.62 | 26.06 ± 0.65b3 | 24.78 ± 0.90b3 | 22.12 ± 0.89b3 | 19.87 ± 0.56a3,b3 | 31.40a3,b3 | 11.60 ± 1.44b3 |
AQ 200 mg/kg | 24.73 ± 0.97 | 24.67 ± 0.97b1 | 22.12 ± 0.64b3 | 21.60 ± 1.34b3 | 17.58 ± 1.44a3,b3 | 40.77a3,b3 | 13.83 ± 1.60a1,b3 |
AQ 400 mg/kg | 25.18 ± 0.80 | 24.03 ± 0.91b1 | 22.87 ± 1.22b3 | 20.92 ± 1.59b3 | 14.36 ± 1.23a3,b3,e2 | 51.62a3,b3,e2 | 15.17 ± 1.87a2,b3 |
CQ 25 mg/kg | 22.68 ± 0.78 | 20.47 ± 1.07a1 | 13.72 ± 1.51a3 | 5.28 ± 2.42a3 | 0.00 ± 0.00a3 | 100.00a3 | 30.00 ± 0.00a3 |
Data are expressed as mean ± SEM; n = 6, a = compared to DW, b = compared to CQ 25 mg/kg, c = compared to BA 100 mg/kg, d = compared to BA 200 mg/kg, e = compared to AQ 100 mg/kg, 1 = P < 0.05, 2 = P < 0.01, 3 = P < 0.001, DW = distilled water, BA = Bersama abyssinica crude extract, AQ = aqueous fraction, CQ = chloroquine, SEM = standard error of mean, MST = mean survival time, D3 = day 3, D4 = day 4, D5 = day 5, D6 = day 6, and D7 = day 7.