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. 2020 Apr 11;10(2):225–244. doi: 10.1016/j.jcmgh.2020.04.003

Figure 2.

Figure 2

Postinflammatory DSS mice exhibit both visceral and somatic hyperalgesia. (A) Visceral pain was assessed by using the visceromotor response to colorectal distention. Kruskal-Wallis test of area under the curve: ∗P < .05; ∗∗P < .01. Controls (CT): n = 15, DSS: n = 15, CT + Abx: n = 13, and DSS + Abx: n = 15, 4 experiments). Somatic pain was assessed 7 days before death by using the automated Von Frey (mechanical, B) and hot plate tests (thermal, C). One-way analysis of variance: ∗∗P < .01; ∗∗∗P < .001, ∗∗∗∗P < .0001 (CT: n = 15, DSS and DSS + Abx: n = 10, CT + Abx: n = 13 for the automated Von Frey test. CT and DSS: n = 15, CT + Abx: n = 16, and DSS + Abx: n = 10 for the hot plate test, 4 experiments). (D) Visceromotor responses were tested before and 1 hour after administration of saline (Vehicle, Veh) or antibiotics into the colon via a double-lumen catheter. No differences were noted in visceral sensitivity before or after administration of saline or antibiotics. Abx, antibiotics; DSS, dextran sulfate sodium.