Table 1.
The characteristics of participants in the discovery and replication populations.
| Overall | Controls | Type 2 diabetes | P value | |
|---|---|---|---|---|
| Discovery population | n = 324 | n = 162 | n = 162 | |
| Age (years)a | 51.40 (±7.65) | 51.39 (±7.35) | 51.41 (±7.97) | 0.997 |
| Sex (male/female)b | 72/252 | 36/126 | 36/126 | 1.000 |
| BMI (<18.5/18.5~23.9/>23.9)b | 1/69/254 | 0/35/127 | 1/34/127 | 0.602 |
| HBP (yes/no)b | 101/223 | 55/107 | 46/116 | 0.337 |
| HDL-cholesterol (mmol/L)c | 1.13 (1.10-1.57) | 1.45 (1.25-1.65) | 1.19 (1.04-1.37) | <0.001 |
| nonHDL-cholesterol (mmol/L)c | 3.50 (2.92-4.10) | 3.62 (3.06-4.15) | 3.29 (2.75-3.95) | 0.007 |
| Replication population | n = 788 | n = 508 | n = 280 | |
| Age (years)a | 49.92 (±7.75) | 42.15 (±9.77) | 64.00 (±6.73) | <0.001 |
| Sex (male/female)b | 338/450 | 91/417 | 247/33 | <0.001 |
| BMI (<18.5/18.5 ~ 23.9/>23.9)b | 26/318/444 | 26/277/205 | 0/41/239 | <0.001 |
| HBP (yes/no)b | 144/644 | 58/450 | 86/194 | <0.001 |
| HDL-cholesterol (mmol/L)c | 1.53 (1.25-1.79) | 1.68 (1.47-1.86) | 1.21 (1.04-1.44) | <0.001 |
| nonHDL-cholesterol (mmol/L)c | 3.22 (2.64-3.76) | 3.30 (2.84-3.83) | 2.98 (2.29-3.58) | <0.001 |
aMean (±SD) is given; bnumbers of each category are given; cmedian (P25-P75) is given.