Table 2.

Associations of the IgG glycans and glycan score for type 2 diabetes in the discovery and replication populations and meta-analyses.

Glycan peak	Glycan structurea	Discovery population (n = 324)		Replication population (n = 788)		Meta-analyses
		OR	P valueb	OR	P valueb	OR	P valueb
Upregulated
GP22	A2BG2S2	2.520	<0.0001	2.535	<0.0001	2.531	<0.0001
GP24	FA2BG2S2	3.611	<0.0001	3.533	<0.0001	3.556	<0.0001
IGP32	FBG2S2/(FBG2+FBG2S1+FBG2S2)	5.392	<0.0001	8.717	<0.0001	6.621	<0.0001
IGP42	GP2n	1.542	0.0003	3.826	<0.0001	1.913	<0.0001
IGP45	GP6n	1.793	<0.0001	5.668	<0.0001	2.132	<0.0001
IGP60	FG1n total/G1n	4.038	<0.0001	4.551	<0.0001	4.349	<0.0001
Downregulated							<0.0001
GP3	A2B	0.392	<0.0001	0.351	<0.0001	0.361	<0.0001
GP5	M5	0.106	<0.0001	0.021	<0.0001	0.026	<0.0001
GP20	FA2FG2S1	0.158	<0.0001	0.017	<0.0001	0.020	<0.0001
IGP46	GP7n	0.232	<0.0001	0.183	<0.0001	0.195	<0.0001
IGP47	GP8n	0.510	<0.0001	0.272	<0.0001	0.313	<0.0001
IGP69	FBG2n/G2n	0.350	<0.0001	0.486	<0.0001	0.435	<0.0001
Glycan score	—	3.309	<0.0001	7.145	<0.0001	3.782	<0.0001

^aStructure abbreviations: F: core fucose; A: number of antennas; B: bisecting GlcNAc; M: number of mannose residues; Gx: number of galactoses; Sx: number of sialic acids linked to galactose; n: neutral glycans. ^bP values < 6.41E-4 was considered statistically significant.