Figure 4.

Five protein complexes identified by the molecular complex detection (MCODE) method in Metascape. Protein–protein interaction enrichment analysis as conducted by Metascape with the BioGrid database (a subanalysis of structure, pathway, and function enrichment clustering). The MCODE algorithm was applied to the protein–protein interaction networks in order to identify neighborhoods where proteins are densely connected. The left panel shows the MCODE network color-coded according to identities. The right panel table shows the corresponding functional labels of the network plots. The top three highest-scoring terms based on p-values derived from GO-enrichment analysis have been retained as the functional labels and are described next to the corresponding components.