Figure 2. ChIP-Seq Reveals a Striking Diversity of Unique and Novel Enhancers in Different Cortical Subregions.
(A) Pie charts showing the proportions (and numbers) of distinct active genomic elements identified by H2K27ac ChIP-seq of the 4 cortical subregions. These numbers are roughly similar to those found by ChIP-seq of other organs.
(B) Dendrogram (left) and correlation matrix of the H3K27ac signals (right) from replicates of the cortical subregions dissected in this experiment versus those from ENCODE were used for subtraction. Note the relatively high correlation of replicates (except ACC) and clustering of signal from cortical tissues.
(C) Heatmaps showing some of the tissue-specific putative enhancers identified in the microdissected cortical subregions.