Scheme 6.

Proposed mechanism for formation of interstrand crosslink’s by bioxalomycin α2 (24) in 5′-CG-3′ duplexes. The iminium synthon is shown in red and the second leaving group is shown in blue, while DNA is shown in purple.

Proposed mechanism for formation of interstrand crosslink’s by bioxalomycin α2 (24) in 5′-CG-3′ duplexes. The iminium synthon is shown in red and the second leaving group is shown in blue, while DNA is shown in purple.