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. Author manuscript; available in PMC: 2020 Jun 18.
Published in final edited form as: Chemistry. 2010 Nov 22;16(44):13020–13029. doi: 10.1002/chem.201001562

Scheme 6.

Scheme 6.

Proposed mechanism for formation of interstrand crosslink’s by bioxalomycin α2 (24) in 5′-CG-3′ duplexes. The iminium synthon is shown in red and the second leaving group is shown in blue, while DNA is shown in purple.