Table 2.
Induction of micronuclei by ionizing radiation of 18F-FDG in human lymphocytes in vitro
| Shielding | Distribution of BNC according to the number of MN | MN/BNC ± SD (%) | CMN/BNC ± SD (%) | NPB/CBN ± SD (‰) | NBUD/CBN ± SD (‰) | CBPI ± SD | |||
|---|---|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | ||||||
| Negative Control | 14 | 1 | 0 | 0 | 1.55 ± 0.19 | 1.48 ± 0.18 | 1.00 ± 0.63 | 0.83 ± 0.75 | 2.09 ± 0.05 |
| 18F-FDG Unshielded | 53 | 3 | 2 | 2 | 7.13 ± 0.70a | 5.92 ± 0.68a | 5.83 ± 0.75a | 4.67 ± 1.75a | 1.60 ± 0.06a |
| 18F-FDG + Lead | 39 | 2 | 1 | 1 | 4.78 ± 0.33ab | 4.22 ± 0.19ab | 1.17 ± 0.75b | 0.50 ± 0.55b | 1.99 ± 0.03ab |
| 18F-FDG + Polymer | 46 | 3 | 1 | 1 | 6.02 ± 0.20ab | 5.10 ± 0.14ab | 2.50 ± 1.05ab | 1.83 ± 0.75ab | 1.88 ± 0.04ab |
| 18F-FDG + Lead + Polymer | 38 | 1 | 1 | 0 | 4.30 ± 0.23ab | 3.98 ± 0.23ab | 1.50 ± 0.55b | 0.83 ± 0.75b | 2.06 ± 0.04b |
Number of binucleated cells analyzed for each individual in each repetition = 1000
BNC binucleated cells, MN micronucleus, CMN cell with one or more micronuclei, NPB nucleoplasmic bridge, NBUD nuclear bud, CBPI Cytokinesis-Block Proliferation Index
a Statistically significant difference from the negative control (p < 0.05)
b Statistically significant difference from the unshielded group (p < 0.05)