Table 2.
Characteristics of the included studies-Part II
| Study | Case type |
Sample (size (n)/Age range (years)/Male (%)) | Adjusted RR (95%CI) |
Covariates adjustment | NOS score |
|
|---|---|---|---|---|---|---|
| Cases | Controls | |||||
| Aletaha-2019 [17] | IBD | 68,535/18–64/NM | 42,371,769/18–64/NM | 3.5 (3.3–3.8) | Age, sex, region, and insurance | 7 |
| Bae-2017 [14] | IBD | 40,843/All/60.2 | 122,529/All/60.2 | 3.41 (2.61–4.44) | Age, sex, and insurance | 7 |
| CD | 12,646/All/69.1 | 3.74 (2.47–5.65) | ||||
| UC | 28,197/All/59.2 | 3.31 (2.49–4.40) | ||||
| Burisch-2019 [16] | IBD | 11,777/≥18/NM |
1 for 5 matcheda /≥18/NM |
2.11 (1.66–2.67) | Age, sex | 8 |
| CD | NM/≥18/NM | 3.59 (2.32–5.54) | ||||
| UC | NM/≥18/NM | 1.67 (1.21–2.30) | ||||
| Cohen-2008-1 [13] | IBD | 18,603/≥18/44.3 | 66,969/≥18/44.3 | 2.72 (2.43–3.04) | Age, sex, region, and insurance | 7 |
| CD | 9267/≥18/43.0 | 37,068/≥18/43.0 | 2.76 (2.40–3.18) | |||
| UC | 11,220/≥18/46.0 | 44,880/≥18/46.0 | 2.76 (2.40–3.18) | |||
| Cohen-2008-2 [13] | IBD | 16,139/≥18/45.5 | 64,556/≥18/45.5 | 2.05 (1.84–2.29) | Age, sex, region, and insurance | 7 |
| CD | 7404/≥18/42.7 | 29,604/≥18/42.7 | 2.37 (2.02–2.77) | |||
| UC | 10,104/≥18/45.7 | 40,416/≥18/45.7 | 2.16 (1.88–2.49) | |||
| Halling-2017 [12] | IBD | 47,325/All/46 | 92,839/All/46 | 1.8 (1.5–2.0) | Age, sex, and region | 8 |
| CD | 13,343/All/42 | 26,172/All/42 | 2.1 (1.6–2.8) | |||
| UC | 31,066/All/47 | 60,951/All/47 | 1.6 (1.3–1.9) | |||
| Kappelman-2011 [11] | IBD | 1242/≤20/55 | 3353/≤20/54 | 9.6 (3.9–23.8) | Age, sex, and region | 8 |
| CD | 737/≤20/56 | 1997/≤20/56 | 15.7 (4.6–53.7) | |||
| UC | 488/≤20/53 | 1310/≤20/52 | 3.6 (0.8–16.1) | |||
| Park-2019 [15] | IBD | 35,581/≤80/61.6 | 142,324/≤80/61.6 | 4.24 (3.25–5.52) | Age, sex | 8 |
| CD | 11,803/≤80/70.9 | 47,212/≤80/70.9 | 5.59 (3.32–9.41) | |||
| UC | 23,737/≤80/56.9 | 94,948/≤80/56.9 | 3.90 (2.86–5.32) | |||
| Puolakka-2014 [19] | RA | 7209/≥17/32 | NM/NM/NM | 0.74 (0.51–1.03) | Age, sex | 7 |
| Kronzer-2019 [18] | RA | 821/≥18/27 | 2455/≥18/27 | 3.82 (1.77–8.41) | Age, sex, region, race, BMI, education, smoking, CCI | 6 |
| Weng-2007 [10] | IBD | 12,601/≤89/47.5 | 50,404/≤89/47.5 | 1.9 (1.5–2.3) | Age, sex, insurance, and smoking | 9 |
| CD | 4021/≤89/44.1 | 1 for 4 matched/≤89/44.1 | 2.5 (1.8–3.5) | |||
| UC | 7525/≤89/49.3 | 1 for 4 matched/≤89/49.3 | 1.5 (1.2–2.0) | |||
| Yang-2018 [9] | IBD | 43,281/19–75/70.1 | 1,127,261/19–75/48.4 | 1.60 (1.52–1.68) | No | 6 |
| CD | 13,925/19–75/63.5 | 1.47 (1.34–1.61) | ||||
| UC | 29,356/19–75/57.6 | 1.67 (1.57–1.77) | ||||
BMI Body Mass Index, CCI Charlson Comorbidity Index, CD Crohn Disease, IBD Inflammatory Bowel Diseases, RA Rheumatoid Arthritis, RR Relative Risk, UC Ulcerative Colitis
aThe sample size of CD and UC was not mentioned; however, each patient was paired with 5 age- and sex-matched 5 individuals from the general population