Table 3.
Joint associations of GRS and MRS with LC incidence
| Group | MRS risk groupa | GaRS risk groupa | Cases | Controls | OR (95%CI) | ||
|---|---|---|---|---|---|---|---|
| Model 1b | Model 2c | Model 3d | |||||
| All participants | Low | Low | 8 | 368 | Ref. | Ref. | Ref. |
| (Ncase/control = 143/1460) | High | 9 | 362 | 0.91 (0.33–2.51) | 0.86 (0.31–2.38) | 0.77 (0.25–2.40) | |
| High | Low | 41 | 330 | 5.61 (2.62–13.51) | 5.11 (2.36–12.37) | 2.29 (0.92–6.32) | |
| High | 85 | 400 | 9.08 (4.40–21.35) | 7.88 (3.75–18.73) | 3.50 (1.44–9.50) | ||
| p trend | < 0.0001 | < 0.0001 | 0.0005 | ||||
| Ever smokers | Low | Low | 10 | 164 | Ref. | Ref. | Ref. |
| (Ncase/control = 123/712) | High | 17 | 192 | 1.48 (0.62–3.67) | 1.47 (0.61–3.70) | 1.38 (0.51–3.95) | |
| High | Low | 29 | 162 | 3.99 (1.78–9.61) | 4.06 (1.80–9.87) | 1.83 (0.68–5.25) | |
| High | 67 | 194 | 7.19 ( 3.39-16.69 | 7.03 (3.26-16.57) | 3.35 (1.32-9.30) | ||
| p trend | < 0.0001 | < 0.0001 | 0.0038 | ||||
| Heavy smokers | Low | Low | 6 | 46 | Ref. | Ref. | Ref. |
| (Ncase/control = 69/205) | High | 15 | 56 | 2.48 (0.76–9.01) | 2.12 (0.62–8.02) | 1.78 (0.50–6.89) | |
| High | Low | 14 | 43 | 2.81 (0.82–10.77) | 3.13 (0.88–12.52) | 1.96 (0.53–8.03) | |
| High | 34 | 60 | 4.01 (1.33–13.92) | 4.44 (1.42–16.06) | 3.58 (1.10–13.25) | ||
| p trend | 0.0225 | 0.0097 | 0.0319 | ||||
GRS genetic risk score, MRS methylation risk score, LC lung cancer, OR odds ratio, CI confidence interval, Ref. reference category
aThe GRS/MRS median value was used as cut-point for low-/high-risk groups
bModel 1: adjusted for batch (3 subsets) and leukocyte composition
cModel 2: like model 1, additionally adjusted for age and sex
dModel 3: like model 2, additionally adjusted for smoking status and pack-years