Table 1.
The prognostic significance of ITGA and ITGB superfamily members in predicting RFS in HGSOC patients in TCGA dataset
| Variables | Number of patients | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | ||
| Age | 405 | 1.005 (0.993–1.018) | 0.391 | / | / |
| Stage | 0.035 | 0.065 | |||
| Early | 23 | 1 | 1 | ||
| Late | 382 | 2.255 (1.060–4.796) | 2.046 (0.956–4.379) | ||
| Debulking | 0.546 | / | |||
| Optimal | 302 | 1 | / | / | |
| Suboptimal | 103 | 1.100 (0.807–1.501) | / | / | |
| ITGA1 | 405 | 0.882 (0.570–1.362) | 0.570 | / | / |
| ITGA2 | 405 | 0.778 (0.528–1.147) | 0.205 | / | / |
| ITGA4 | 405 | 1.060 (0.679–1.655) | 0.798 | / | / |
| ITGA5 | 405 | 1.152(0.950–1.396) | 0.150 | / | / |
| ITGA6 | 405 | 0.863 (0.723–1.029) | 0.100 | 0.888 (0.739–1.068) | 0.207 |
| ITGA7 | 405 | 1.086 (0.916–1.287) | 0.341 | / | / |
| ITGA8 | 405 | 1.040 (0.714–1.515) | 0.838 | / | / |
| ITGA9 | 405 | 1.054 (0.754–1.451) | 0.788 | / | / |
| ITGA10 | 405 | 0.893 (0.618–1.292) | 0.549 | / | / |
| ITGB1 | 405 | 1.327 (1.002–1.757) | 0.048 | 1.341 (1.018–1.767) | 0.037 |
| ITGB2 | 405 | 1.039 (0.928–1.162) | 0.506 | / | / |
| ITGB3 | 405 | 0.769 (0.451–1.311) | 0.335 | / | / |
| ITGB4 | 405 | 1.054 (0.936–1.186) | 0.385 | / | / |
| ITGB5 | 405 | 1.080 (0.911–1.280) | 0.375 | / | / |
| ITGB6 | 405 | 0.874 (0.659–1.159) | 0.349 | / | / |
| ITGB7 | 405 | 0.834 (0.614–1.133) | 0.245 | / | / |
| ITGB8 | 405 | 1.124 (0.962–1.314) | 0.142 | 0.888 (0.739–1.068) | 0.207 |