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Molecular Profiling of the Patient’s Tumor
| Profile | EGFR | HER2/neu | KRAS |
|---|---|---|---|
| IHC | +3 | +2 | |
| Increase in DNA copy number | High polysomy (≥ 4 EGFR copies in ≥ 40% of cells) | ||
| FISH | Not amplified | Amplified (6.1) | |
| Mutation (EGFR/HER2) | Wild type | Wild type | |
| KRAS mutation | Wild type |
Abbreviations: IHC, immunohistochemistry; EGFR, epidermal growth factor receptor; FISH, fluorescent in situ hybridization; HER2, human epidermal growth factor receptor 2.
