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. 2020 Jun 11;11:1168. doi: 10.3389/fimmu.2020.01168

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Copyright © 2020 Morris, Chapman, Pichichero and Broderick.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Predicted response trajectories during an episode of AOM. Output trajectories aim to fit the available data on activation levels at rest, AOM, and recovery states as well as predicting the course of events during the processes of pathogenesis and recovery. Responses adhered closely to available reference constraints and additionally predicted behavior of unmeasured entities. Lines show medians of the 44 refined models for each entity in (A) nasopharynx and (B) periphery compartments, interpolating the predicted response dynamics during the course of AOM pathogenesis and recovery (*p < 0.05 for interaction between otitis-prone condition and infection stage by BH-corrected ANOVA during dynamic response). Dots show reference data where available. Blue, NOP; red, sOP.