Figure 8.

Early response motifs. (A) Network entities initially engaged by bacterial infection during AOM pathogenesis in the nasopharynx. (B) Absolute activation of these early response elements immediately following bacterial infection: lines show medians for the 44 refined models. (C) Relative change in activation compared to resting levels early after bacterial infection in NOP and sOP settings, normalized to maximum activation for each entity (*p < 0.05, BH-corrected Wilcoxon test; stars denote the group with the higher median).