Table 3.
Association of Circulating E-Selectin with Indices of Systolic and Diastolic Function at Year 30.
| Log-transformed Year 7 E-selectin | Log-transformed Year 15 E-selectin | |||||
|---|---|---|---|---|---|---|
| Echocardiographic Variable (Dependent Variable) | N | β coefficient per SD increase (SE) | P value | N | β coefficient per SD increase (SE) | P value |
| Systolic Function | ||||||
| GLS | 1680 | 1778 | ||||
| Unadjusted | 0.50 (0.06) | <0.001 | 0.52 (0.06) | <0001 | ||
| Model 1* | 0.22 (0.06) | <0.001 | 0.19 (0.06) | 0.002 | ||
| Circumferential Strain | 1619 | 1713 | ||||
| Unadjusted | 0.35 (0.09) | <0.001 | 0.31 (0.09) | <0.001 | ||
| Model 1* | 0.19 (0.10) | 0.05 | 0.09 (0.09) | 0.35 | ||
| Diastolic Function | ||||||
| e’ average | 1751 | 1849 | ||||
| Unadjusted | −0.18 (0.05) | <0.001 | −0.18 (0.05) | <0.001 | ||
| Model 1* | −0.08 (0.05) | 0.14 | −0.03 (0.05) | 0.53 | ||
| E/e’ | 1719 | 1819 | ||||
| Unadjusted | 0.08 (0.06) | 0.17 | 0.13 (0.05) | 0.02 | ||
| Model 1* | 0.03 (0.06) | 0.64 | 0.01 (0.05) | 0.81 | ||
GLS = global longitudinal strain
*
Adjusted for age, sex, race, systolic blood pressure, anti-hypertensive medication use, total cholesterol, diabetes, number of cigarettes per day, body mass index, creatinine, field center, and image quality score. Covariates obtained at the corresponding exam as E-selectin measurements were used for analyses.