Table 4.
Association of Circulating ICAM-1 and Indices of Systolic and Diastolic Function at Year 30.
| Log transformed Year 7 ICAM-1 | Log-transformed Year 15 ICAM-1 | |||||
|---|---|---|---|---|---|---|
| Echocardiographic Variable (Dependent Variable) | N | β coefficient per SD increase (SE) | P value | N | β coefficient per SD increase (SE) | P value |
| Systolic Function | ||||||
| GLS | 1434 | 1863 | ||||
| Unadjusted | 0.29 (0.07) | <0.001 | 0.45 (0.06) | <0.001 | ||
| Model 1* | 0.06 (0.08) | 0.41 | 0.18 (0.06) | 0.004 | ||
| Circumferential Strain | 1383 | 1794 | ||||
| Unadjusted | 0.29 (0.10) | 0.005 | 0.49 (0.09) | <0.001 | ||
| Model 1* | 0.24 (0.12) | 0.04 | 0.31 (0.10) | 0.001 | ||
| Diastolic Function | ||||||
| e’ average | 1495 | 1934 | ||||
| Unadjusted | −0.09 (0.06) | 0.12 | −0.17 (0.05) | <0.001 | ||
| Model 1* | 0.04 (0.06) | 0.51 | −0.02 (0.05) | 0.63 | ||
| E/e’ | 1472 | 1903 | ||||
| Unadjusted | 0.15 (0.06) | 0.02 | 0.26 (0.05) | <0.001 | ||
| Model 1* | −0.04 (0.07) | 0.59 | 0.07 (0.06) | 0.20 | ||
GLS = global longitudinal strain; ICAM-1 = intercellular adhesion molecule-1.
*
Adjusted for age, sex, race, systolic blood pressure, anti-hypertensive medication use, total cholesterol, diabetes, number of cigarettes per day, body mass index, creatinine, field center, and image quality score. Covariates obtained at the corresponding exam as ICAM-1 measurements were used for analyses.