Table I.
Experimental design and treatment protocol.
| Control group (n = 3) | Nonseptic synovitis group (n = 6) | Septic arthritis group (n = 8) | ||||
|---|---|---|---|---|---|---|
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| Injected joint | Non-injected joint | Injected joint | Non-injected joint | Injected joint | Non-injected joint | |
| Day 0 | Injected with saline | No injection | Injected with LPS | No injection | Injected with E. coli | No injection |
| Day 1 | Arthroscopic lavage + IA gentamicin | No treatment | Arthroscopic lavage + IA gentamicin | Arthroscopic lavage + IA gentamicin | Arthroscopic lavage + IA gentamicin | Arthroscopic lavage + IA gentamicin |
| Day 2 to 4 | IV RLP gentamicin | No treatment | IV RLP gentamicin | IV RLP gentamicin | IV RLP gentamicin | IV RLP gentamicin |
| Day 1 to 6 | All horses were administered IV penicillin, gentamicin, and phenylbutazone | |||||
| Day 7 to 21 | All horses were administered oral trimethoprim-sulfamethoxazole | |||||
LPS — lipopolysaccharide; IV — intravenous; IA — intra-articular; RLP — regional limb perfusion.