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QL suppressed apoptosis and inflammation in DOX-induced CHF rats. (A, B) IHC images showing that QL downregulated Bax and upregulated Bcl-2. (C, D) ICH images showing that QL treatment downregulated MMP-2 and TIMP-2. (E) Analysis of Bax and Bcl-2 positive integral optical density. (F) ELISA demonstrated that QL substantially downregulated MMP-2 and TIMP-2. *p < 0.05, **p < 0.01 vs. control group. #p < 0.05, ##p < 0.01 vs. CHF group.
