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. 2020 May 20;9(1):1766192. doi: 10.1080/20013078.2020.1766192

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© 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group on behalf of The International Society for Extracellular Vesicles.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Exosome HSP70 levels correlates with the response to treatment. (a) Exosomal HSP70 variation ratio between diagnosis and the first tumour evaluation according to the clinical status. CR/PR = Complete/Partial response (n = 6), SD = Stable disease (n = 3), PD = Progression disease (n = 11), p = 0.0043. (b)–(d): Case study of the correlation between HSP70 levels in exosomes (blue lines) and their response to the different cures (C2, C4, etc.). CA-15-3 and CEA clinical tumour marker measurements, when available, are indicated by a red line. EOR = End of radiotherapy, EOS = End of study, SD = Stable Diseased PD = Progression disease, PR = Partial response. Panels below show the respective scan imagery. Metastasis is visualised by black spots (patient 1) and red arrows (patients 2 and 3).