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. 2020 Jun 9;11:798. doi: 10.3389/fphar.2020.00798

Figure 2.

Figure 2

YYWY suppressed tumor growth in NSCLC-bearing mice. Lewis cells were subcutaneously implanted into C57BL/6 mice; and the model mice were administrated with 0.9% normal saline (200 ul, 14 days, ig.), YYWY (18.8 g/kg/day, 14 days, ig.) or DDP (2 mg/kg/4 days, 30 days, ip.) (n = 8), respectively. (A) Tumor volumes were calculated after measuring the length and width of the tumors daily using Vernier calipers every day. At the endpoint, the tumor tissues were harvested for the detection of the tumor weight and tumor volume. (B) Representative H&E and immunohistochemical staining of Ki67 were carried out in the tumor tissue from Lewis-bearing mice. Ki67 cells positive for the indicated proteins were counted from 5 fields for each tumor sample. Scale bar: 100μm. (C) Expression of Bcl-2, Bax and Caspase3 were measured by WB. β-Actin is a loading control. The values represent the mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001 compared to the control group.