Table 1.
Coagulation profile in critically ill COVID-19 patients.
| Patient 1 | Patient 2 | Patient 3 | Patient 4 | Reference range | |
|---|---|---|---|---|---|
| Age (years) | 77 | 68 | 42 | 68 | |
| BMI | 38.1 | 26.1 | 26.1 | 27.8 | |
| Day of illness | 4 | 5 | 4 | 4 | |
| SOFA score | 12 | 11 | 12 | 11 | |
| Thromboplastin time (%) | 65 | 88 | 47 | 88 | 70–130 |
| aPTT (s) | 37 | 62 | 69 | 51 | 25–37 |
| Fibrinogen (mg/dL) | 741 | 380 | 639 | 707 | 190–498 |
| Antithrombin-activity (%) | 49 | 54 | 101 | 51 | 80–128 |
| D-dimer (ng/mL) | 3315 | 12,639 | 13,221 | 4159 | <500 |
| Platelets (103/μL) | 391 | 172 | 251 | 174 | 146–328 |
| Factor II (%) | 61.7 | 47.6 | 51.4 | 65.7 | 75–129 |
| Factor V (%) | 98.2 | 96 | 121.4 | 163.4 | 80–148 |
| Factor VII (%) | 57.1 | 73.7 | 24.2 | 68.4 | 48–148 |
| Factor VIII (%) | 339.6 | 73.7 | 261.8 | 339.5 | 48–139 |
| Factor IX (%) | 150.8 | 106.1 | 130 | 97 | 68–133 |
| Factor XI (%) | 64 | 51 | 60 | 82 | 69–144 |
| Factor XII (%) | 34.8 | 29.8 | 32.1 | 47.4 | 66–146 |
| Factor XIII (%) | 120.9 | 39 | 58.8 | 46.3 | 70–155 |
| v. Willebrand antigen (%) | >600 | >600 | >600 | 536 | 60–150 |
| Protein C-activity (%) | 53 | 59 | 87 | 65 | >72 |
| Free protein S-antigen (%) | 55 | 48 | 45 | 37 | 68–116 |
| DRVVT screen (s) | 53.8 | 42.6 | 54.7 | 49.6 | 28.4–45.8 |
| DRVVT ratio | 1.19 | 1.20 | 1.19 | 1.22 | 0.93–1.40 |
| Lupus sensitive PTT (s) | 35.9 | 35.4 | 58.1 | 33.6 | 23.1–38.4 |
| Anti-cardiolipin IgM (U/mL) | 2.7 | 10.3 | <1.0 | 1.7 | <20 |
| Anti-cardiolipin IgG (U/mL) | 6.7 | 3.9 | 4 | 6.4 | <20 |
| Anti-ß2-glykoprotein IgM (U/mL) | 1.7 | 1.1 | <1.1 | <1.1 | <20 |
| Anti-ß2-glykoprotein IgG (U/mL) | <6.4 | 7.7 | <6.4 | <6.4 | <20 |
| ADAMTS-13 (%) activity | 36 | 19 | 36 | 28 | 40–130 |
| PAI-Ag (ng/mL) | 36.2 | >62.4 | 10.9 | >62.4 | 7–43 |
| Factor V-mutation | Wild type | Wild type | Wild type | Wild type | |
| Factor II-mutation | Wild type | Wild type | Wild type | Wild type | |
BMI: body-mass-index; SOFA score: sepsis-related organ failure assessment score; aPTT: activated partial thromboplastin time; DRVVT: diluted-Russel-Viper-Venom-Test; PAI: plasminogen activator inhibitor; AT levels are pre-substitution values.