Table 3. Description of 13 hub genes of pancreatic ductal adenocarcinoma.

No.	Gene symbol	Full name	Function
1	TOP2A	DNA topoisomerase II alpha	Controlling and altering the topologic states of DNA during transcription. Involving in chromosome condensation, chromatid separation, and the relief of torsional stress.
2	CDK1	Cyclin dependent kinase 1	Essential for G1/S and G2/M phase transitions of eukaryotic cell cycle and mitotic cyclins.
3	RRM2	Ribonucleotide reductase regulatory subunit M2	Catalyzing the formation of deoxyribonucleotides from ribonucleotides.
4	PRC1	Protein regulator of cytokinesis 1	A substrate of several CDKs and necessary for polarizing parallel microtubules and concentrating the factors responsible for contractile ring assembly.
5	NEK2	NIMA related kinase 2	A serine/threonine-protein kinase that is involved in mitotic regulation.
6	ZWINT	ZW10 interacting kinetochore protein	Clearly involved in kinetochore function.
7	DTL	Denticleless E3 ubiquitin protein ligase homolog	Cellular response to DNA damage stimulus.
8	MELK	Maternal embryonic leucine zipper kinase	G2/M transition of mitotic cell cycle apoptotic process.
9	CENPF	Centromere protein F	Associating with the centromere-kinetochore complex and playing a role in chromosome segregation during mitotis.
10	CEP55	Centrosomal protein 55	Cranial skeletal system development and establishment of protein localization.
11	ANLN	Anillin actin binding protein	An actin-binding protein that plays a role in cell growth and migration, and in cytokinesis.
12	ASPM	Abnormal spindle microtubule assembly	Essential for normal mitotic spindle function in embryonic neuroblasts and regulating neurogenesis.
13	ECT2	Epithelial cell transforming 2	A guanine nucleotide exchange factor and transforming protein that is related to Rho-specific exchange factors and yeast cell cycle regulators.

Notes.

CDKs

cyclin-dependent kinases