TABLE 2.

Pleiotropy estimated among the fetal/maternal specific effect of birth weight and stroke as well as its subtypes.

Stroke	π00	π10	π01	π11	π11/(π10 + π11)	π11/(π01 + π11)	LRT	p-value
Fetal effect of birth weight
AIS	0.789	0.128	0.058	0.024	0.158	0.293	3.32	0.068
CES	0.748	0.169	0.071	0.012	0.066	0.145	0.16	0.689
LAS	0.721	0.196	0.057	0.026	0.117	0.313	0.66	0.418
SVS	0.790	0.127	0.045	0.038	0.230	0.458	5.95	0.015
Maternal effect of birth weight
AIS	0.807	0.105	0.042	0.047	0.309	0.528	22.62	1.97E−06
CES	0.772	0.139	0.051	0.037	0.210	0.420	5.87	0.015
LAS	0.731	0.180	0.047	0.041	0.186	0.466	4.59	0.032
SVS	0.759	0.152	0.074	0.015	0.090	0.169	1.50E−03	0.969

The last two columns are the likelihood ratio test (LRT) statistic and p-value of hypothesis testing for pleiotropy between birth weight and stroke. π₁₀, the proportion of SNPs that are associated with stroke; π₀₁, the proportion of SNPs that are associated with birth weight; π₁₁/(π₁₀ + π₁₁), the proportion of SNPs that are associated with stroke are also associated with birth weight; π₁₁/(π₀₁ + π₁₁), the proportion of SNPs that are associated with birth weight are also associated with stroke.