Table 4.
Associations between DRD2 and ANKK1 gene polymorphisms and selected clinical parameters in schizophrenic patients (N = 198)
| Parameter | rs1799732 | rs6276 | rs1800497 | |||
|---|---|---|---|---|---|---|
| χ2* H# | p | χ2* H# | p | χ2* H# | p | |
| Psychiatric illness in the family | 0.08 | 0.777 | 9.54 | 0.002 | 1.98 | 0.159 |
| Neurological illness in the family | 0.06 | 0.807 | 1.08 | 0.299 | 2.52 | 0.112 |
| Age of onset (years) | 0.85 | 0.653 | 1.01 | 0.603 | 0.98 | 0.611 |
| Time delay from onset to diagnosis | 4.75 | 0.093 | 0.03 | 0.987 | 2.41 | 0.299 |
| < 1 month | ||||||
| 1–6 months | ||||||
| > 6 months | ||||||
| Withdrawal of symptoms after neuroleptics | 0.99 | 0.321 | 1.57 | 0.211 | 1.61 | 0.204 |
| Number of psychiatric hospitalizations | 2.97 | 0.226 | 0.41 | 0.814 | 3.65 | 0.161 |
| Longest episode (weeks) | 1.25 | 0.535 | 3.90 | 0.142 | 0.52 | 0.770 |
| Clinical course | 0.01 | 0.996 | 2.00 | 0.368 | 1.04 | 0.596 |
| Episodes of relapses and remissions | ||||||
| Chronic course | ||||||
| Chronic course with social withdrawal | ||||||
| MMSE | 3.07 | 0.216 | 2.18 | 0.337 | 0.47 | 0.789 |
| PANSS | ||||||
| Total | 2.51 | 0.285 | 0.33 | 0.846 | 0.70 | 0.705 |
| Positive | 4.83 | 0.090 | 0.67 | 0.717 | 0.76 | 0.684 |
| Negative | 1.32 | 0.517 | 1.34 | 0.512 | 2.64 | 0.267 |
| General | 2.37 | 0.306 | 0.02 | 0.992 | 0.50 | 0.779 |
| CGI-SCH | ||||||
| Total | 0.70 | 0.703 | 0.38 | 0.828 | 0.62 | 0.734 |
| Positive | 0.62 | 0.734 | 1.54 | 0.462 | 1.80 | 0.406 |
| Negative | 0.40 | 0.819 | 0.97 | 0.615 | 0.83 | 0.66 |
| Depressive | 0.93 | 0.627 | 0.82 | 0.66 | 1.73 | 0.421 |
| Cognitive | 0.66 | 0.718 | 0.73 | 0.693 | 2.42 | 0.298 |
| Total severity of schizophrenia | 0.83 | 0.66 | 0.27 | 0.872 | 0.03 | 0.987 |
| SDS | 0.16 | 0.924 | 0.85 | 0.654 | 1.78 | 0.411 |
* χ2 coefficient for allele comparison in Pearson’s test (genotype comparisons were abandoned due to the small numbers expected for certain genotypes)
#H coefficient, Kruskal–Wallis test for genotype comparison