Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Oct 29;69(4):623–637. doi: 10.1093/sysbio/syz070

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019. Published by Oxford University Press on behalf of the Society of Systematic Biologists.

This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model)

PMC Copyright notice

Figure 2. — Temporal evolution of the spatial model reveals observable morphologic differences between TIC-driven and non-TIC-driven tumors, as observed by others. We plot representative results of simulations of two tumors, each simulated on a square lattice of size . Top: a tumor simulated with and . We notice, as have Enderling et al. (2009) and Sottoriva et al. (2010), a “patchy” clonal architecture, and nonuniform edge. Bottom: a tumor simulated with , that is, no proliferative hierarchy. We note smooth edges, radial patterns of clonal architecture, and relatively faster population growth, reaching 70,000 cells in less than time steps. To reach a similar size, the tumor with symmetric division probability of took 35,000 time steps. Color bars denote number of mutations present in a given clone, note that the top scale is about 1/3 of bottom scale.

Inline graphic — Temporal evolution of the spatial model reveals observable morphologic differences between TIC-driven and non-TIC-driven tumors, as observed by others. We plot representative results of simulations of two tumors, each simulated on a square lattice of size . Top: a tumor simulated with and . We notice, as have Enderling et al. (2009) and Sottoriva et al. (2010), a “patchy” clonal architecture, and nonuniform edge. Bottom: a tumor simulated with , that is, no proliferative hierarchy. We note smooth edges, radial patterns of clonal architecture, and relatively faster population growth, reaching 70,000 cells in less than time steps. To reach a similar size, the tumor with symmetric division probability of took 35,000 time steps. Color bars denote number of mutations present in a given clone, note that the top scale is about 1/3 of bottom scale.