Table 1.

Pathologic Changes in COVID-19 and Activated Protein C Counteractions

Pathologic Change	Activated Protein C Counteraction
Increased thrombin generation	Cleaves activated factorV, which reduces prothrombinase activity
Increased factorVIII activity	Cleaves activated factorVIII shutting down propagation of thrombin generation
Increased plasminogen activator inhibitor-1 activity, which inhibits fibrinolysis	Reduces thrombin-activated fibrinolysis inhibitor activation by slowing thrombin generation and facilitates fibrinolysis by neutralizing plasminogen activator inhibitor-1
Increased endothelial cell proinflammatory signaling	Propagates anti-inflammatory signaling in endothelial cells through protease-activated receptor 1

Abbreviation: COVID-19, coronavirus disease 2019.