TABLE 1.
Univariable and multivariable Cox regression analysis of risk factors associated with disease-free survival (DFS)
| Univariable analysis |
Multivariable analysis |
|||||
|---|---|---|---|---|---|---|
| E/N | HR (95% CI) | p | E/N | HR (95% CI) | p | |
| AGE | 92/495 | 1.027 (0.996,1.060) | 0.090 | |||
| Race | ||||||
| Caucasian | 47/281 | Reference | ||||
| Non-Caucasian | 8/51 | 0.702 (0.332,1.488) | 0.356 | |||
| Clinical T-stage | <0.001* | 0.001* | ||||
| T1 | 17/175 | Reference | 17/174 | Reference | ||
| T2 | 36/174 | 2.264 (1.271,4.033) | 0.006 | 36/174 | 1.858 (1.033,3.345) | 0.039 |
| T3-T4 | 23/53 | 5.867 (3.127,11.007) | <0.001 | 23/53 | 3.593 (1.810,7.133) | <0.001 |
| Pathology T-stage | ||||||
| T1-T2 | 14/186 | Reference | ||||
| T3-T4 | 78/303 | 3.65 (2.062,6.46) | <0.001 | |||
| Prognostic grade | <0.001* | 0.002* | ||||
| 1-2 | 13/193 | Reference | 10/154 | Reference | ||
| 3 | 12/100 | 1.783 (0.813,3.91) | 0.149 | 11/84 | 1.672 (0.705,3.967) | 0.244 |
| 4 | 13/64 | 3.133 (1.452,6.762) | 0.004 | 13/54 | 2.746 (1.159,6.504) | 0.022 |
| 5 | 54/138 | 7.11 (3.878,13.036) | <0.001 | 42/109 | 3.828 (1.787,8.202) | 0.001 |
| Lymph node status | 0.147 | |||||
| Yes | 83/417 | Reference | ||||
| No | 8/72 | 0.605 (0.293,1.251) | 0.175 | |||
| ELK1 | 92/492 | 1.513 (1.281,1.787) | <0.001 | 76/401 | 1.321 (1.066,1.637) | 0.011 |
| ELK3 | 92/492 | 1.064 (0.872,1.297) | 0.541 | |||
| ELK4 | 92/492 | 0.991 (0.800,1.228) | 0.935 | |||
| BGN | 92/492 | 1.296 (1.086,1.546) | 0.004 | |||
| COL1A1 | 92/492 | 1.104 (1.039,1.172) | 0.001 | 76/401 | 1.042 (0.953,1.138) | 0.366 |
| SFRP4 | 92/492 | 1.181 (1.021,1.367) | 0.025 | |||
| FLNC | 92/492 | 0.753 (0.578,0.980) | 0.035 | |||
| GSN | 92/492 | 0.885 (0.696,1.124) | 0.315 | |||
| TPM2 | 92/492 | 0.765 (0.521,1.124) | 0.173 | |||
| GSTM2 | 92/492 | 0.910 (0.715,1.158) | 0.445 | |||
| FAM13C | 92/492 | 0.620 (0.462,0.833) | 0.001 | |||
| KLK2 | 92/492 | 0.941 (0.762,1.161) | 0.568 | |||
| AZGP1 | 92/492 | 0.866 (0.708,1.060) | 0.163 | |||
| SRD5A2 | 92/492 | 0.581 (0.433,0.780) | <0.001 | 76/401 | 0.833 (0.585,1.184) | 0.308 |
| TPX2 | 92/492 | 1.435 (1.288,1.599) | <0.001 | |||
| FOXM1 | 92/492 | 1.143 (1.056,1.238) | 0.001 | |||
| CDC20 | 92/492 | 1.537 (1.352,1.749) | <0.001 | |||
| CDKN3 | 92/492 | 1.239 (1.130,1.359) | <0.001 | |||
| CDK1 | 92/492 | 1.273 (1.128,1.436) | <0.001 | |||
| KIF11 | 92/492 | 1.277 (1.136,1.437) | <0.001 | |||
| KIAA0101 | 92/492 | 1.274 (1.110,1.462) | 0.001 | |||
| NUSAP1 | 92/492 | 1.500 (1.308,1.722) | <0.001 | |||
| CENPF | 92/492 | 1.215 (1.117,1.321) | <0.001 | |||
| ASPM | 92/492 | 1.468 (1.285,1.677) | <0.001 | |||
| BUB1B | 92/492 | 1.539 (1.312,1.805) | <0.001 | |||
| RRM2 | 92/492 | 1.362 (1.184,1.567) | <0.001 | |||
| DLGAP5 | 92/492 | 1.340 (1.193,1.506) | <0.001 | |||
| BIRC5 | 92/492 | 1.287 (1.147,1.443) | <0.001 | |||
| KIF20A | 92/492 | 1.518 (1.328,1.735) | <0.001 | |||
| PLK1 | 92/492 | 1.384 (1.241,1.542) | <0.001 | |||
| TOP2A | 92/492 | 1.471 (1.286,1.683) | <0.001 | |||
| TK1 | 92/492 | 1.322 (1.153,1.517) | <0.001 | |||
| PBK | 92/492 | 1.282 (1.163,1.412) | <0.001 | |||
| ASF1B | 92/492 | 1.257 (1.124,1.406) | <0.001 | |||
| SKA1 | 92/492 | 1.336 (1.119,1.595) | 0.001 | |||
| RAD54L | 92/492 | 1.541 (1.339,1.774) | <0.001 | |||
| PTTG1 | 92/492 | 1.252 (1.125,1.393) | <0.001 | |||
| MCM10 | 92/492 | 1.313 (1.185,1.455) | <0.001 | |||
| PRC1 | 92/492 | 1.411 (1.258,1.584) | <0.001 | |||
| DTL | 92/492 | 1.227 (1.111,1.355) | <0.001 | |||
| CEP55 | 92/492 | 1.191 (1.087,1.305) | <0.001 | |||
| RAD51 | 92/492 | 1.136 (1.021,1.264) | 0.019 | |||
| CENPM | 92/492 | 1.153 (0.990,1.343) | 0.067 | |||
| CDCA8 | 92/492 | 1.512 (1.286,1.778) | <0.001 | |||
| ORC6 | 92/492 | 1.411 (1.252,1.590) | <0.001 | |||
Abbreviation: CI, confidence interval; E/N, the number of events and the number of samples; HR, hazard ratio.
Note: The shading segregate from top to bottom, the TCF subfamily genes, genes in the OncotypeDX panel and genes in the Prolaris panel, respectively.
*
Global p-value.