Table 1.
Agreement analysis between CrCl24h and formulae estimating renal function
| All ICU days (n = 51,604) | CrCl24h < 130 ml/min/1.73 m2 (n = 41,290) | CrCl24h ≥ 130 ml/min/1.73 m2 (n = 10,314) | |
|---|---|---|---|
| Median (IQR) (ml/min/1.73 m2) | |||
| CrCl24h | 73 (37;118) | 58 (30;88) | 166 (145;200) |
| CrClCG | 83 (50;127) | 70 (43;103) | 145 (116;183) |
| eGFRMDRD | 87 (50;130) | 72 (42;109) | 143 (115;185) |
| eGFRCKD-EPI | 88 (51;108) | 75 (43;99) | 116 (104;130) |
| Correlation with CrCl24h = Spearman correlation coefficient | |||
| CrClCG | 0.63° | 0.62° | 0.18° |
| eGFRMDRD, | 0.59° | 0.60° | 0.15° |
| eGFRCKD-EPI | 0.69° | 0.72° | 0.19° |
| Mean bias (95% CI) = mean difference CrCl24h – estimator (ml/min/1.73 m2) | |||
| CrClCG | − 11 (− 11;-10) | − 20 (− 20;-19) | 25 (23;27) |
| eGFRMDRD | − 14 (− 15;− 14) | − 23 (− 23;− 23) | 21 (19;23) |
| eGFRCKD-EPI | 3 (3;4) | − 12 (− 13;− 12) | 66 (64;67) |
| Precision = SD of the bias (ml/min/1.73 m2) | |||
| CrClCG | 55 | 41 | 83 |
| eGFRMDRD | 61 | 46 | 94 |
| eGFRCKD-EPI | 48* | 26* | 62* |
| Accuracy = percentage within 30% of CrCl24h | |||
| CrClCG | 47 | 45 | 58 |
| eGFRMDRD | 45 | 43 | 56 |
| eGFRCKD-EPI | 50 | 51 | 45 |
n number of ICU days; CrCl24h creatinine clearance measured by 24-h urine collection, corrected for body surface area; IQR interquartile range; CrClCG estimated creatinine clearance by the Cockcroft – Gault formula, corrected for body surface area; eGFRMDRD estimated glomerular filtration rate by the 4-variable Modification of Diet in Renal Disease formula; eGFRCKD-EPI estimated glomerular filtration rate by the Chronic Kidney Disease Epidemiology Collaboration formula; SD standard deviation; CI confidence interval
°p < 0,001
*Best performing