Table 4.
Sensitivity and Specificity of Putative and Existing Sarcopenia Metrics for Slow Gait†
| Cut point | HIV | Uninfected | |||
|---|---|---|---|---|---|
| Sensitivity | Specificity | Sensitivity | Specificity | ||
| Muscle weakness metrics | |||||
| Men | |||||
| Grip/BMI | <1.05 | 17/59 (29%) | 124/139 (89%) | 13/53 (25%) | 120/142 (85%) |
| Grip | <35.5 | 24/59 (41%) | 76/140 (54%) | 30/53 (57%) | 82/144 (57%) |
| Grip/TBF | <1.66 | 24/47 (51%) | 59/105 (56%) | 25/36 (69%) | 59/111 (53%) |
| Grip/arm lean mass | <6.08 | 30/47 (64%) | 34/105 (32%) | 27/36 (75%) | 44/111 (40%) |
| Grip/weight | <0.45 | 30/59 (51%) | 77/139 (55%) | 35/53 (66%) | 74/142 (52%) |
| Women | |||||
| Grip/BMI | <0.79 | 22/69 (32%) | 63/81 (78%) | 11/35 (31%) | 27/40 (68%) |
| Grip | <20.0 | 7/71 (10%) | 75/82 (91%) | 2/36 (6%) | 37/40 (92%) |
| Grip/TBF | <0.65 | 17/54 (31%) | 49/61 (80%) | 3/27 (11%) | 17/26 (65%) |
| Grip/arm lean mass | <3.26 | 1/54 (2%) | 61/61 (100%) | 0/27 (0%) | 25/26 (96%) |
| Grip/weight | <0.34 | 33/69 (48%) | 49/81 (60%) | 17/35 (49%) | 22/40 (55%) |
| Putative and existing sarcopenia metrics | |||||
| Men | |||||
| FNIH Grip/BMI | <1.00 | 15/59 (25%) | 127/139 (91%) | 11/53 (21%) | 128/142 (90%) |
| FNIH Grip | <26.0 | 10/59 (17%) | 128/140 (91%) | 6/53 (11%) | 135/144 (94%) |
| EWGSOP | — | 8/54 (15%) | 118/133 (89%) | 4/45 (9%) | 124/133 (93%) |
| Women | |||||
| FNIH Grip/BMI | <0.56 | 6/69 (9%) | 76/81 (94%) | 2/35 (6%) | 37/40 (92%) |
| FNIH Grip | <16.0 | 4/71 (6%) | 81/82 (99%) | 0/36 (0%) | 39/40 (98%) |
| EWGSOP | — | 3/68 (4%) | 79/81 (98%) | 2/35 (6%) | 39/39 (100%) |
Notes: BMI = body mass index; EWGSOP = European Working Group on Sarcopenia in Older People (inclusive of walking speed, grip strength, skeletal muscle index); FNIH = Foundation of the National Institutes of Health Sarcopenia Project; SDOC = Sarcopenia Definitions and Outcomes Consortium, where weak grip was defined as <35.5 kg for a man and <20.0 kg for a woman + slow gait of either <1.0 m/s or 0.8 m/s; TBF = total body fat.
†Sensitivity: count of individuals exhibiting muscle weakness among those with slowness (gait speed < 1.0 m/s) shown, with percentages. Specificity: count of individuals not exhibiting muscle weakness among those not exhibiting slowness (gait speed > 1.0 m/s) shown, with percentages.