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[Preprint]. 2020 Aug 13:2020.04.22.056127. [Version 3] doi: 10.1101/2020.04.22.056127

Figure 2. TMPRSS2 expression in the alveoli.

Figure 2.

a, b) Single-cell RNA sequencing reanalyses of TMPRSS2 transcript abundance in alveoli from lung parenchyma (26). Summative observations from all donors. a) Percentage of TMPRSS2+ cells within each cell type shows TMPRSS2 transcripts in 35ยท5% of alveolar type II cells. Airway cells (basal, mitotic, ciliated, club) are not shown. Violin plots represent expression, each data point denotes a cell. b) TMPRSS2 transcripts in ACE2+ alveolar type II cells. c) Immunofluorescence of alveoli shows apical colocalization of ACE2 and TMPRSS2 (white arrows). AT2: alveolar type II. AT1: alveolar type I. Macs: Macrophages. Mono: Monocytes. DC: dendritic cells. Other immune cells: B cells, mast cells, natural killer/T cells. Endo: Endothelial. Fibro: Fibroblasts/myofibroblasts. CPM: counts per million.