FIGURE 2.

Cost-effectiveness of POC as a function of S-LAB per test cost, result return time, result return probability, and ART initiation probability. Cost effectiveness of POC at varied cost, result return time, result return probability, and ART initiation probability of S-LAB. Varied S-LAB per test cost is shown in each colored box, from $0.40 less than POC to $10 less than POC. Along the horizontal axis of each box, result return probability of S-LAB is shown, from 15% less than to the same as POC. Along the vertical axis of each box, result return time of S-LAB is shown, from 60 days longer to 10 days longer than POC. Each figure panel shows probability of ART initiation of S-LAB, from 20% (A) less than POC to the same as POC (D). For each combination of parameters, the cost effectiveness of POC is shown. Blue: The ICER of POC is ≤50% of the per capita GDP; S-LAB is weakly dominated. Grey: The ICER of POC is >50% of the per capita GDP and ≤100% of the per capita GDP. Black: The ICER of POC is >100% of the per capita GDP and S-LAB is ≥50% the per capita GDP and ≤100% the per capita GDP. At base-case costs, the ICER of POC remained ≤50% of the per capita GDP and the preferred strategy over S-LAB unless S-LAB result return and ART initiation probabilities were the same as POC and result return time was reduced to 10 days. At lower S-LAB costs, POC was the preferred strategy over S-LAB unless S-LAB result return time, result return probability, and ART initiation probability were close to those of POC, representing marked improvements compared with base-case values. S-LAB, strengthened laboratory-base early infant HIV diagnosis.