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. 2020 Mar 4;161(7):1670–1681. doi: 10.1097/j.pain.0000000000001858

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Copyright © 2020 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the International Association for the Study of Pain.

This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

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Figure 4. — Effect of Ab181 on a maxadilan-induced increase in DBF in rats 3.25 hours after treatment. Rats were given intravenous (i.v.) bolus injection of Ab181 (0.1, 0.3, 1, 3, and 10 mg/kg, n = 7-8 rats/group). Three hours later, after obtaining a postdrug baseline (BL), maxadilan at a dose of 10 ng (in 20-µL DPBS) was injected intradermally. The DBF was measured by a laser Doppler imager. Solid triangle represents % change from baseline (mean ± SEM, left axis), and open bar represents resulting serum concentration (mean ± SD, right axis). Control: Dummy antibody + vehicle (n = 13 rats). **P < 0.01, ****P < 0.0001 compared with the control group by one-way ANOVA followed by Dunnett's MCT. ANOVA, analysis of variance; DBF, dermal blood flow; DBPS, Dulbecco's phosphate-buffered saline; MCT, multiple comparison test.