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. 2020 Jun 17;12:88. doi: 10.1186/s13148-020-00879-5

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Knockdown of G9A in TICs (LCSC1 and LCSC4) strongly suppressed tumor growth in vivo. a Knockdown of G9A in LCSC1 significantly inhibited the tumor growth in mouse xenografts as shown in growth curves (left panel) and as resected tumors (four replicates for control and five replicates for knockdown, right panel). b Measurement of tumor weight (*P < 0.05 control vs. knocked down) shows the suppression of tumor growth is statistically significant. c Knockdown of G9A in LCSC4 significantly inhibited the tumor growth in mouse xenografts as shown in growth curves (left panel) and as resected tumors (right panel). d Measurement of tumor weight (***P < 0.001 control vs. knocked down) shows the suppression of tumor grown is statistically significant. e IHC staining of the tumors from the mouse xenografts shows reduced G9A expression (for validation of its knockdown) and H3K9Me2 level and increased expression of FOXP1 and SP5 both in LCSC1 and LCSC4 (× 20 magnification). (For t test: *P < 0.05, **P < 0.01, and ***P < 0.001)