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. Author manuscript; available in PMC: 2020 Jun 18.
Published in final edited form as: Mol Cancer Res. 2019 Jun 3;17(9):1828–1841. doi: 10.1158/1541-7786.MCR-18-1154

Figure 4.

Figure 4.

MINK1 binds to and is negatively regulated by APC. A, co-IP of MINK1 with full-length, endogenous APC in HeLa and U2OS cells. B, co-IP of MINK1 with C-terminally truncated APC in Colo320 and SW480 colorectal cancer cells; both cell lines lack the WT allele. C, Changes in MINK1 proteins levels in response to siRNA-mediated depletion of APC and/or β-catenin measured by WB. Shown are means and SD relative to control samples from four independent transfections. Significance relative to control determined by two-way ANOVA followed by Dunnett multiple comparison test (*, P < 0.05; **, P < 0.01).