Table 1.
Overlap between β-catenin–independent APC targets identified in this study and proteins misexpressed in colorectal polyps and/or tumors (32)
| Protein name (identified by TMT and/or LFQ) | Log2 fold change |
q Value |
Log2 fold change (Wiśniewski et al. 2015 - ref 32) |
|||||
|---|---|---|---|---|---|---|---|---|
| APC siRNA/control | β-Catenin siRNA/control | APC+ β-catenin siRNA/control | APC siRNA/control | β-Catenin siRNA/control | APC+ β-catenin siRNA/control | Polyps/normal | Tumor/normal | |
| 60S Ribosomal export protein NMD3 (TMT/LFQ) | 2.79/4.54 | 0.89/2.62 | 2.02/3.77 | <0.001 | 0.019/0.027 | <0.001 | 0.67 | 1.46 |
| Peptidyl-prolyl cis-trans isomerase FKBP10 (TMT/LFQ) | 1.16/1.13 | 0.49/0.74 | 1.00/1.03 | 0.004/0.04 | 0.062/0.238 | 0.003/0.087 | 0.06 | 1.95 |
| Melanoma-associated antigen D2 (LFQ) | 1.52 | 1.04 | 1.29 | 0.021 | 0.09 | 0.047 | 1.07 | 2.21 |
| Nucleolar protein 58 (LFQ) | 0.93 | 0.48 | 1.03 | 0.059 | 0.238 | 0.098 | 1.5 | 1.25 |
| 6-pyruvoyl tetrahydrobiopterin synthase (TMT) | 1.97 | 0.51 | 1.29 | <0.001 | 0.057 | 0.007 | 1.67 | 0.66 |
| Glycerophosphocholine phosphodiesterase GPCPD1 (TMT) | 1.46 | 0.41 | 0.94 | 0.012 | 0.083 | 0.007 | 1.34 | 1.19 |
| Hermansky-Pudlak syndrome 5 protein (TMT) | 0.74 | 0.28 | 0.67 | 0.002 | 0.154 | 0.011 | 1.14 | 0.68 |
| Ubiquitin carboxyl-terminal hydrolase 8 (TMT) | 1.04 | 0.44 | 0.73 | 0.003 | 0.069 | 0.006 | 0.58 | −0.23 |
| Zinc finger protein 622 (TMT) | 1.26 | −0.19 | 0.74 | 0.006 | 0.283 | 0.006 | 0.44 | 0.80 |
| Ras-related protein Rab-14 (TMT/LFQ) | −1.77/−1.48 | −0.08/−0.24 | 1.39/−1.01 | <0.001/0.025 | 0.568/0.384 | <0.001/0.086 | −0.55 | −0.27 |
| Aldehyde dehydrogenase family 1 member A3 (LFQ) | −1.98 | −0.58 | 1.45 | 0.009 | 0.192 | 0.041 | −1.14 | −0.69 |
| Dolichol-phosphate mannosyltransferase subunit 1 (TMT) | −1.09 | −0.07 | 0.93 | 0.004 | 0.617 | 0.008 | −0.97 | 0.07 |
| EH domain-containing protein 1 (TMT) | −0.60 | −0.20 | 0.60 | 0.006 | 0.229 | 0.014 | −0.95 | −0.78 |
| Ferrochelatase, mitochondrial (TMT) | −1.17 | −0.04 | 0.71 | 0.005 | 0.751 | 0.011 | −0.33 | −1.54 |
| Leucine zipper protein 1 (TMT) | −1.73 | −0.20 | 1.24 | <0.001 | 0.267 | 0.006 | 0.85 | −0.20 |
| Moesin (TMT) | −1.15 | −0.09 | 0.79 | 0.003 | 0.543 | 0.006 | −0.85 | −1.06 |
| Nonhistone chromosomal protein HMG-14 (TMT) | −1.28 | −0.20 | 0.85 | 0.007 | 0.247 | 0.006 | −0.81 | −0.66 |
| Protein NDRG1 (TMT) | −1.55 | −0.41 | 1.18 | 0.010 | 0.098 | 0.004 | −0.17 | −0.67 |