Fig 5. SSAO inhibition suppressed nitrotyrosine expression.

Representative photographs of nitrotyrosine stained cells and histograms summarising expression. (Fig A) It is minimally expressed in the kidneys of control animals but increased in the kidneys of diabetic mice. Both telmisartan and SSAOi significantly suppressed nitrotyrosine expression, a finding similarly seen with the combination of SSAOi and telmisartan treatment. (Fig B) Nitrotyrosine glomerular specific staining. Control IgG₁ staining was performed to confirm specific staining (not shown). Results are expressed as mean ± SE. (***p<0.001 vs control, ###p<0.001 vs DM) n = 6–8. Bar = 400μm DM, Diabetes Mellitus; SSAOi, Semicarbazide Sensitive Amine Oxidase Inhibitor; Telmi, telmisartan.