Table 3. ARWMC scores and MARS of patients with CADASIL according to cysteine mutation type.
| Cysteine-involving | Cysteine-sparing | OR (95% CI) | p-value* | |
|---|---|---|---|---|
| ARWMC scores, median (IQR) | ||||
| Frontal | 3 (2–3) | 3 (2–3) | 1.99 (0.68–5.85) | 0.211 |
| Parieto-occipital | 3 (2–3) | 3 (1–3) | 1.88 (0.61–5.85) | 0.275 |
| Anterior temporal | 1 (0–2) | 0 (0–0.75) | 9.70 (2.89–32.6) | <0.001 |
| External capsule | 1 (0–2) | 0.5 (0–2) | 1.67 (0.66–4.27) | 0.281 |
| Infratentorial | 0 (0–0) | 0 (0–0.75) | 0.54 (0.15–1.91) | 0.337 |
| Basal ganglia | 1 (0–2) | 1 (0–2) | 0.92 (0.37–2.30) | 0.867 |
| MARS, median (IQR) | ||||
| Infratentorial | 0 (0–1) | 1 (0–2.5) | 0.54 (0.20–1.41) | 0.206 |
| Deep | 1 (0–4) | 2.5 (0–6) | 0.64 (0.24–1.68) | 0.361 |
| Lobar | 0 (0–2) | 0 (0–4.75) | 0.77 (0.28–2.14) | 0.622 |
* Adjusted for covariates including age, hypertension, diabetes mellitus, and smoking.
ARWMC, age-related white matter change; CADASIL, cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy; IQR, interquartile range; MARS, microbleed anatomical rating scale; OR, odds ratio.