Table 4. Frequency of anterior temporal lobe T2 hyperintensities in brain MRI and R544C and R75P NOTCH3 missense mutations in the present study and other studies.
| CADASIL series, number (%) | Anterior temporal lobe involvement | R544C | R75P | Country |
|---|---|---|---|---|
| Markus et al, 2002 | 41/46 (89) | 0/48 (0) | 0/48 (0) | UK |
| Kim et al, 2006 | 14/26 (54) | 5/27 (19) | 16/27 (59) | Korea |
| Choi et al, 2006 | 4/20 (20) | 15/20 (75) | 2/20 (10) | Korea |
| Lee et al, 2009 | 9/21 (43) | 10/21 (48) | 0/21 (0) | Taiwan |
| Wang et al, 2010 | 22/48 (46) | 0/57 (0) | 1/57 (2) | China |
| Ueda et al, 2015 | 36/51 (71) | 0/70 (0) | 8/70 (11) | Japan |
| Present study | 43/79 (54) | 12/79 (15) | 18/79 (23) | Korea |
CADASIL, cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy; MRI, magnetic resonance imaging.