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. 2018 Jun 4;29(6):2716–2727. doi: 10.1093/cercor/bhy140

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Figure 4. — Altered cortical excitability in TgF344-AD rats. During awake but idling behavior spontaneously occurring high-voltage spindles (HVSs) characterized as hypersynchronous, negative voltage 7–8 Hz spike–wave discharges were observed in the cortical EEG of both WT and TgF344-AD rats. (A) HVSs isolated or in clusters, exhibited a wax and wane pattern, and were particularly pronounced in frontal cortex (upper and middle traces). Bottom is an enlargement of single HVS event and its corresponding time-frequency spectrogram. (B, C) In comparison to WT rats (n = 5), TgF344-AD rats (n = 5) showed significantly higher incidence of HVS events, however, the pattern and duration of HVS events did not differ, (**P < 0.001).