Table 4. Family history based criteria* for germline testing with MMR-intact, MMR-deficient and Lynch syndrome.
| Overall (N = 456) |
MMR-intact (N = 146) |
Abnormal tumour testing | p | |||||
|---|---|---|---|---|---|---|---|---|
| MMR-deficient (N = 148) |
Lynch syndrome (N = 162) |
MMR-intact versus MMR-deficient | MMR-intact versus Lynch syndrome | MMR-deficient versus Lynch syndrome | ||||
| Family history* | Yes | 135 (30%) | 28 (19%) | 19 (13%) | 88 (54%) | 0.13 | <0.01 | <0.01 |
| No | 321 (70%) | 118 (81%) | 129 (87%) | 74 (46%) | ||||
*
Family history based criteria defined as Amsterdam and/or Bethesda criteria, per study.