Table 3.

Clinico-histopathologic characteristics ofpatients with acute dAEsand skin biopsy performed during same-day outpatient dermatology consultation with targeted therapy interruption

Clinical diagnosis	Anticancer therapy	Histopathologic features and diagnosis
Grade 2 maculopapular rash	BTK inhibitor	Mild interface and superficial dermal perivascular lymphocytic dermatitis with evidence of mild vascular damage, consistent with a drug reaction.
Grade 2 maculopapular Fig. 2(a)	EGFR inhibitor	Perivascular lymphocytic dermatitis with scattered eosinophils, consistent with a drug hypersensitivity reaction.
Grade 2 maculopapular rash Fig. 2(b)	ERK inhibitor	Interface, perivascular and interstitial lympho-eosinophilic dermatitis with evidence of mild vascular damage, consistent with a drug hypersensitivity reaction.
Grade 3 maculopapular rash Fig. 2 (c)	mTOR protein inhibitor	Mixed pattern dermatitis with eosinophils, consistent with a drug reaction.